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KMID : 0923620110110040191
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Immune Network
2011 Volume.11 No. 4 p.191 ~ p.195
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Stimulatory Effect of ?-glucans on Immune Cells
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Kim Hyung-Sook
Hong Geun-Pyo
Kim Young-Soo
Han Sang-Bae
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Abstract
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?-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infective and anti-cancer effects, have been well studied, it is still unclear how ?-glucans exert their activities. However, recent studies on the ?-glucan receptors shed some light on their mechanism of action. Since ?-glucans have large molecular weights, they must bind surface receptors to activate immune cells. In this review, we summarize the immunopharmacological activities and the potential receptors of ?-glucans in immune cells.
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KEYWORD
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?-glucan, Receptors, Immune cells
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